Background: Pancreatic debridement is a lifesaving operation in patien
ts with severe acute pancreatitis and pancreatic or peripancreatic nec
rosis. Even in the presence of gallstones, cholecystectomy may be avoi
ded during the procedure, but definitive treatment of the stones is ne
eded at a later stage. Methods: Five patients (median age 58 years) un
derwent laparoscopic cholecystectomy, at a median time interval of 15
months, after pancreatic debridement via a dome-shaped upper abdominal
incision for seven acute pancreatitis. The use of alternative methods
for primary access, additional cannulae to enable division of adhesio
ns, the harmonic scalpel, and the fundus first technique made the lapa
roscopic approach possible and safe. Results: The median operating tim
e was 130 min. Four patients were discharged home the first or second
postoperative day. One patient required a ''mini-laparotomy'' for drai
nage of a periumbilical hematoma and was discharged on the 13th day. C
onclusions: Laparoscopic cholecystectomy can be considered an effectiv
e and safe approach for the treatment of gallstones in patients who ha
ve undergone pancreatic debridement.