CYCLIC GUANIDINES .5. SYNTHESIS OF NOVEL BENZODIAZEPINOID AND RELATEDSYSTEMS BY INTRAMOLECULAR ELECTROPHILIC AROMATIC-SUBSTITUTION

Authors
ESSER F POOK KH CARPY A LEGER JM
Citation
F. Esser et al., CYCLIC GUANIDINES .5. SYNTHESIS OF NOVEL BENZODIAZEPINOID AND RELATEDSYSTEMS BY INTRAMOLECULAR ELECTROPHILIC AROMATIC-SUBSTITUTION, Synthesis, (1), 1994, pp. 77-82
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
1
Year of publication
1994
Pages
77 - 82
Database
ISI
SICI code
0039-7881(1994):1<77:CG.SON>2.0.ZU;2-Q
Abstract
A convenient route to pentacyclic benzodiazepines and quinoxalines is reported, which simultaneously represent cyclic guanidines. Five new h eterocyclic sing systems are described and the rules governing the reg ioselectivity of some of the ring closure reactions are studied. The s tructure of one of the products is confirmed by X-ray analysis. Scope and versatility of the process are indicated by several examples.