ESOPHAGEAL NARROWING IN CHRONIC GRANULOMATOUS-DISEASE

A 14 year-old boy with X-linked chronic granulomatous disease (CGD) de veloped a long smooth narrowing at the mid oesophagus with severe dysp hagia. Endoscopy revealed a normal mucosa and biopsy showed non-specif ic acute inflammatory changes. Bacterial cultures of the biopsy specim ens were sterile. Combined treatment with antibiotics and steroids res ulted in a transitory remission, but symptoms recurred after 2.5 month s. One second course of steroids and antibiotics lead to a long-term r emission. Oesophagogram was more useful than endoscopy to evaluate the severity of the stricture. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.