OUTER-MEMBRANE PROTEINS OF KLEBSIELLA-PNEUMONIAE AFTER EXPOSURE TO CIPROFLOXACIN

Suppression of bacterial growth of two Klebsiella pneumoniae strains a fter a short time exposure to ciprofloxacin at suprainhibitory concent rations was found (postantibiotic effect-PAE). PAEs induced by ciprofl oxacin at 2 x MIC were 4.1 h and 5.3 h for the strains tested, the con centration of 4 x MIC manifested a suppression of the bacterial growth which lasted 5.9 h and 6.3 h. Delay of regrowth of K. pneumoniae stra ins exposed to suprainhibitory concentrations of quinolones was shown also by other authors. New information concerning the outer membrane p rotein profile of K. pneumoniae after PAE has been found. SDS-PAGE ana lysis revealed that outer membrane protein patterns isolated from K. p neumoniae strains treated with a suprainhibitory concentration of cipr ofloxacin did not show apparent changes as compared to controls.