ASYMMETRIC MICHAEL ADDITIONS OF HOMOCHIRAL MAGNESIUM AMIDES

Authors
BUNNAGE ME DAVIES SG GOODWIN CJ WALTERS IAS
Citation
Me. Bunnage et al., ASYMMETRIC MICHAEL ADDITIONS OF HOMOCHIRAL MAGNESIUM AMIDES, Tetrahedron : asymmetry, 5(1), 1994, pp. 35-36
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
5
Issue
1
Year of publication
1994
Pages
35 - 36
Database
ISI
SICI code
0957-4166(1994)5:1<35:AMAOHM>2.0.ZU;2-J
Abstract
The first asymmetric Michael addition of a homochiral magnesium amide is presented. Methylation of the resultant p-amino magnesium enolate w as found to occur with excellent stereoselectivity, providing a direct strategy for the synthesis of homochiral syn-alpha-methyl-beta-amino acids.