M. Desclozeaux et al., CHARACTERIZATION OF 2 SP1 BINDING-SITES OF THE HUMAN SEX-DETERMINING SRY PROMOTER, Biochimica et biophysica acta, N. Gene structure and expression, 1397(3), 1998, pp. 247-252
To investigate the molecular basis of the human SRY gene regulation, w
e have examined the significance of two potential binding sites for th
e transcription factor Sp1 (Sp1A: -124 to -131 and Sp1B: -147 to -154)
by DNase I footprinting and gel mobility shift assays. Cotransfection
experiments in Drosophila SL2 cells implicated Spl protein in the tra
nscriptional activation of the SRY promoter. (C) 1998 Elsevier Science
B.V.