IMPERFECT INTERFACES

Authors
YSERN X LI HM MARIUZZA RA
Citation
X. Ysern et al., IMPERFECT INTERFACES, Nature structural biology, 5(6), 1998, pp. 412-414
Citations number
25
Categorie Soggetti
Biophysics,Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
5
Issue
6
Year of publication
1998
Pages
412 - 414
Database
ISI
SICI code
1072-8368(1998)5:6<412:>2.0.ZU;2-1
Abstract
The crystal structure of a T cell receptor bound to a self peptide-maj or histocompatibility complex antigen reveals poor shape complementari ty in the interface between the two proteins, as well as large conform ational changes in the T cell receptor combining site upon ligand bind ing.