ASSOCIATION OF PRIMARY ANTIPHOSPHOLIPID SYNDROME WITH INHERITED ACTIVATED PROTEIN-C RESISTANCE

Authors
PICILLO U DELUCIA D PALATIELLO E SCUOTTO A MARCIALIS MR PEZZELLA S TIRRI G
Citation
U. Picillo et al., ASSOCIATION OF PRIMARY ANTIPHOSPHOLIPID SYNDROME WITH INHERITED ACTIVATED PROTEIN-C RESISTANCE, Journal of rheumatology, 25(6), 1998, pp. 1232-1234
Citations number
18
Categorie Soggetti
Rheumatology
Journal title
Journal of rheumatology → ACNP
ISSN journal
0315162X
Volume
25
Issue
6
Year of publication
1998
Pages
1232 - 1234
Database
ISI
SICI code
0315-162X(1998)25:6<1232:AOPASW>2.0.ZU;2-H
Abstract
A 65-year-old man had had arterial thromboses of the lower limbs and c erebral region for several years; tests revealed anticardiolipin, anti phosphatidylserine, anti-beta(2)-glycoprotein I antibodies, and lupus anticoagulant, As well, both phenotypic and genotypic resistance to ac tivated protein C was found. Antiphospholipid antibodies have been rep orted to interfere in different ways with the functions of protein C; in our patient the simultaneous existence of inherited resistance to a ctivated protein C could account for the thrombophilic status underlyi ng the diffuse and serious arterial thromboses.