CLASTOGENICITY OF ANTHRAQUINONES IN V79 AND IN 3 DERIVED CELL-LINES EXPRESSING P450 ENZYMES

Citation
S. Simi et al., CLASTOGENICITY OF ANTHRAQUINONES IN V79 AND IN 3 DERIVED CELL-LINES EXPRESSING P450 ENZYMES, Mutation research. Mutation research letters, 347(3-4), 1995, pp. 151-156
Citations number
24
Categorie Soggetti
Genetics & Heredity",Toxicology
ISSN journal
01657992
Volume
347
Issue
3-4
Year of publication
1995
Pages
151 - 156
Database
ISI
SICI code
0165-7992(1995)347:3-4<151:COAIVA>2.0.ZU;2-V
Abstract
The clastogenicity of seven anthraquinones was investigated in a V79 C hinese hamster cell line expressing only the reductive pathway enzymes and in three derived cell lines transfected and expressing three rat cytochrome P450 (1A1, 1A2, 2B1). The results have shown that chromosom al aberrations are modulated in similar manner both in parental and tr ansfected V79 cell lines, suggesting that the clastogenicity of these compounds is not mediated by cytochrome P450 dependent monooxygenases.