S. Simi et al., CLASTOGENICITY OF ANTHRAQUINONES IN V79 AND IN 3 DERIVED CELL-LINES EXPRESSING P450 ENZYMES, Mutation research. Mutation research letters, 347(3-4), 1995, pp. 151-156
The clastogenicity of seven anthraquinones was investigated in a V79 C
hinese hamster cell line expressing only the reductive pathway enzymes
and in three derived cell lines transfected and expressing three rat
cytochrome P450 (1A1, 1A2, 2B1). The results have shown that chromosom
al aberrations are modulated in similar manner both in parental and tr
ansfected V79 cell lines, suggesting that the clastogenicity of these
compounds is not mediated by cytochrome P450 dependent monooxygenases.