DEVELOPMENT OF NOVEL MAGNETIC SENSING FOR BRAIN LESION USING FUNCTIONAL MAGNETIC PARTICLES

Real-time sensing of a brain lesion under operation on the brain is in vestigated. We selected a combination of the functional magnetic parti cles and small and high sensitive magnetic sensor, the magneto-impedan ce (MI) sensor, for the sensing method. At first, we detected a magnet ic field of an agarose gel containing magnetite particles using the MI sensor. It was found that a magnetization of the magnetite by a stati c magnetic field is necessary for the detection. We also tried to dete ct the magnetite particles in a rat tumor which was transplanted under the skin of the rat leg. The magnetite cationic liposomes, at which t he magnetite particles were coated with a cationic lipid and phospholi pids membrane, were directly injected in the tumor and magnetized by t he static magnetic field generator at 1.8 T. By using the MI sensor, t he magnetic field distribution of the MCL was detected, and its distri bution indicated that the MCL is localized in the tumor.