T. Habu et al., MEMBRANE MICROSTRUCTURE EVALUATED WITH SO LUTE PERMEABILITIES THROUGHCOLLAGEN-GEL FLAT MEMBRANES PREPARED IN DIFFERENT CONDITIONS, Kagaku kogaku ronbunshu, 24(2), 1998, pp. 211-216
Permeability for 14 solutes of four flat membranes of type 1 atelocoll
agen prepared by different methods using crosslinking with glutaraldeh
yde are analyzed by the tortuous capillary pore model with their water
contents. The results suggest that aggregation of atelocollagen molec
ule and crosslinking density in the membrane depend on the preparation
condition of the membrane. Microstructure of the membranes is discuss
ed with the results obtained from the analysis with the tortuous capil
lary pore model referring to the dependency of the solute permeabiliti
es on molecular weight of the solutes. In conclusion, we find that var
ious microstructures including heterogeneous ones, are obtainable by c
ontrolling the preparation method of collagen membrane, despite the fa
ct that the collagen membrane was a hydrogel. A collagen membrane prep
ared by the our method is expected to be applied to hybrid artificial
organ needed for controlling mass transfer in it because the collagen
membrane has a molecular sieve effect at all molecular weights caused
by the microstructure.