HISPIDOSPERMIDIN, A NOVEL PHOSPHOLIPASE-C INHIBITOR PRODUCED BY CHAETOSPHAERONEMA-HISPIDULUM (CDA) MOESZ NR-7127 .2. ISOLATION, CHARACTERIZATION AND STRUCTURAL ELUCIDATION

Authors
OHTSUKA T ITEZONO Y NAKAYAMA N SAKAI A SHIMMA N YOKOSE K SETO H
Citation
T. Ohtsuka et al., HISPIDOSPERMIDIN, A NOVEL PHOSPHOLIPASE-C INHIBITOR PRODUCED BY CHAETOSPHAERONEMA-HISPIDULUM (CDA) MOESZ NR-7127 .2. ISOLATION, CHARACTERIZATION AND STRUCTURAL ELUCIDATION, Journal of antibiotics, 47(1), 1994, pp. 6-15
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
1
Year of publication
1994
Pages
6 - 15
Database
ISI
SICI code
0021-8820(1994)47:1<6:HANPIP>2.0.ZU;2-5
Abstract
Hispidospermidin (1) is a novel phospholipase C inhibitor produced by Chnetosphaeronema hispidulum (Cda) Moesz NR 7127. Its structure (C25H4 7N3O) has been elucidated as a cage compound with a trimethylspermidin e side chain based on various NMR studies, including H-1-H-1 COSY, C-1 3-H-1 COSY, HOHAHA, HMBC, COLOC and long range J C-H resolved 2D spect roscopy. The absolute configuration of 1 has been elucidated by modifi ed MOSHER's method on the (R)- and (S)-MTPA amides of a derivative of 1.