AROHYNAPENE-A AND AROHYNAPENE-B, NEW ANTICOCCIDIAL AGENTS PRODUCED BYPENICILLIUM SP - TAXONOMY, FERMENTATION, AND STRUCTURE ELUCIDATION

Authors
MASUMA R TABATA N TOMODA H HANEDA K IWAI Y OMURA S
Citation
R. Masuma et al., AROHYNAPENE-A AND AROHYNAPENE-B, NEW ANTICOCCIDIAL AGENTS PRODUCED BYPENICILLIUM SP - TAXONOMY, FERMENTATION, AND STRUCTURE ELUCIDATION, Journal of antibiotics, 47(1), 1994, pp. 46-53
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
1
Year of publication
1994
Pages
46 - 53
Database
ISI
SICI code
0021-8820(1994)47:1<46:AAANAA>2.0.ZU;2-X
Abstract
Penicillium sp. FO-2295, a water isolate, was found to produce a serie s of new anticoccidial compounds. Two active compounds, designated aro hynapenes A and B, were isolated from the fermentation broth of the pr oducing strain by solvent extraction and preparative HPLC. Arohynapene A was deduced to be thyl-5,6,7,8-tetrahydronaphtalene)-2,4pentadienoi c acid, and arohynapene B was 6,8-dimethyltetrahydronaphtalene)-2,4-pe ntadienoic acid. Arohynapenes inhibited the growth of Eimeria tenella in an in vitro assay using BHK-21 cells as a host. No schizont in the cells was observed at concentrations ranging above 35.0 mu M and 7.0 m u M for arohynapenes A and B, respectively.