DECREASED KIDNEY UPTAKE OF TC-99M-LABELED FAB' FRAGMENTS IN OVARIAN-CARCINOMA BEARING NUDE-MICE USING A CLEAVABLE CHELATOR

A new Tc-99m labelling method using a cleavable chelator, RP-1, was de veloped. In this study Balb/c mice with ovarian carcinoma xenografts r eceived various Fab' fragments labelled with Tc-99m either directly or via RP-1. Kidney uptake was significantly lower for the RP-1 linked c onjugates. Tumour uptake showed no significant differences between RP- 1 conjugates and directly labelled preparations. In conclusion, with t he use of the cleavable linker RP-1, kidney uptake can be reduced sign ificantly resulting in a lower radiation dose to the kidneys.