SYNTHESIS AND IMMUNOMODULATING ACTIVITY OF LIPOPHILIC ANALOGS OF ACETYLNORMURAMOYL-L-2-AMINOBUTANOYL-D-ISOGLUTAMINE

Authors
LEDVINA M JEZEK J SAMAN D HRIBALOVA V
Citation
M. Ledvina et al., SYNTHESIS AND IMMUNOMODULATING ACTIVITY OF LIPOPHILIC ANALOGS OF ACETYLNORMURAMOYL-L-2-AMINOBUTANOYL-D-ISOGLUTAMINE, Collection of Czechoslovak Chemical Communications, 63(4), 1998, pp. 590-598
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
63
Issue
4
Year of publication
1998
Pages
590 - 598
Database
ISI
SICI code
0010-0765(1998)63:4<590:SAIAOL>2.0.ZU;2-J
Abstract
Acetylnormuramoyl-L-2-aminobutanoyl-D-isoglutamine (7) and its lipophi lic 6-O-octadecanoyl (8) and 6-O-(2-tetradecylhexadecanoyl) (9) deriva tives were prepared and their immunoadjuvant activity and pyrogenicity were tested. Compounds 8 and 9 are less pyrogenic than muramoyl-dipep tide (MDP) and norMDP analog 7. Both lipophilic derivatives 8 and 9 ar e better adjuvants than MDP in cell mediated immunity.