THE EFFECTS OF NEW PLATELET INHIBITORY DRUG E-5510 ON PLATELET DEPOSITION ON AORTIC BIFURCATION GRAFTS - ASSESSMENT BY INDIUM-111-OXIME LABELED PLATELET IMAGING

The effects of a recently synthesized anti-platelet aggregation drug ( E-5510) on platelet deposition in a knitted Dacron aortic graft underw ent preliminary evaluation by In-111 oxime labeled platelet imaging. S even patients undergoing aortofemoral bypass using this graft for occl usive disease were randomized into two groups: those receiving E-5510 and those receiving no medication. This agent was administered for 17 days postoperatively, and on the 14th day In-111 platelets were inject ed and images were acquired at 24, 48, and 72 hours. Platelet deposits in the grafts were assessed by the ratios of graft radioactivity to t hat of the adjacent native iliac arteries. Platelet deposition at the sites of anastomosis and deposition along the entire graft were normal ized by initial deposition at 24 hours, and had significantly decrease d at 72 hours in the three treated patients, while the normalized depo sition increased progressively over time in the remaining four nonmedi cated patients. E-5510 seems to have the potential to inhibit excessiv e platelet deposition on recently implanted grafts.