The cases of two patients with surgically proven splenic hamartomas wi
th ''hot spots'' on Tc-99m phytate SPECT imaging are presented. There
was intense radiocolloid accumulation in the peripheral portion of a l
arge single tumor in one patient, and in each of three isolated tumors
in the other patient. The intense uptake might be related to the func
tion of proliferated reticuloendothelial cells in the tumors. These un
ique findings were not clearly identified on the planar images.