A COMPARISON OF THE RADIOCHEMICAL STABILITY OF DIFFERENT I-131-LABELED METAIODOBENZYLGUANIDINE FORMULATIONS FOR THERAPEUTIC USE

Authors
WAFELMAN AR HOEFNAGEL CA MAES RAA BEIJNEN JH
Citation
Ar. Wafelman et al., A COMPARISON OF THE RADIOCHEMICAL STABILITY OF DIFFERENT I-131-LABELED METAIODOBENZYLGUANIDINE FORMULATIONS FOR THERAPEUTIC USE, Applied radiation and isotopes, 45(2), 1994, pp. 183-189
Citations number
13
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
45
Issue
2
Year of publication
1994
Pages
183 - 189
Database
ISI
SICI code
0969-8043(1994)45:2<183:ACOTRS>2.0.ZU;2-9
Abstract
The results of a stability study of three commercially available formu lations of [I-131]MIBG for therapeutic use and an unstabilized formula tion, stored under various conditions, are presented. The stability wa s followed for 20 days. In all formulations tested, free [I-131]iodide , formed by radiolysis, was the most important radiochemical impurity. The pharmaceutical formulation with the largest amount of stabilizer was radiochemically-but not chemically-most stable.