This study tested the hypothesis that the amount (weight or volume) of
food consumed affects the satiating potency of a food, independent of
its energy content. Normal-weight young men (n = 20) were tested in a
within-subjects design. Subjects were served a milk-based drink or no
drink (control), followed 30 min later by a self-selected lunch and >
4 h later by a self-selected dinner. Milk drinks were equal in energy
content (2088 kJ, or 499 kcal) and had similar proportions of fat (30.
3%), carbohydrate (54.7%), and protein (15%) across three volumes: 300
, 450, and 600 mt. Ratings of palatability, sensory properties, and en
ergy content of the drinks and of hunger completed before consumption
of the preloads were not significantly different among conditions. The
results showed that preload volume affected energy intake at lunch (P
less than or equal to 0.009) such that energy intake was less after t
he 600-mL preload than after the 300-mL preload. This effect was still
present when energy intake at dinner was included (P less than or equ
al to 0.022). At lunch, including energy from the preload, subjects ov
erate relative to the control condition (4323 +/- 322 kJ) after the 30
0- (5263 +/- 321 kJ) and 450-mL (5011 +/- 300 kJ) preloads but not aft
er the 600-mL (4703 +/- 353 kJ) preload. Thus, the best adjustment for
the energy in the preloads was with the largest, least energy-dense d
rink. Consistent with the effects on intake, the volume of the drinks
affected ratings of hunger and fullness. These results indicate that t
he volume consumed is an important determinant of satiety after milk d
rinks under these conditions.