POLYGENIC CONTROL OF THE EXPRESSION OF BIOLOGICAL-ACTIVITIES OF AN ANTITUMOR POLYSACCHARIDE, LENTINAN

Authors
MAEDA YY TAKAHAMA S KOHARA Y YONEKAWA H
Citation
Yy. Maeda et al., POLYGENIC CONTROL OF THE EXPRESSION OF BIOLOGICAL-ACTIVITIES OF AN ANTITUMOR POLYSACCHARIDE, LENTINAN, International journal of immunopharmacology, 19(9-10), 1997, pp. 469-472
Citations number
10
Categorie Soggetti
Immunology,"Pharmacology & Pharmacy
Journal title
International journal of immunopharmacology → ACNP
ISSN journal
01920561
Volume
19
Issue
9-10
Year of publication
1997
Pages
469 - 472
Database
ISI
SICI code
0192-0561(1997)19:9-10<469:PCOTEO>2.0.ZU;2-Q
Abstract
Genetic studies were carried out on two in vivo responses of lentinan, delayed type-acute phase responses (DT-APR) and vascular dilation and hemorrhage (VDH). Linkage analyses showed that DT-APR was controlled by two recessive genes, Itnr1 and ltnr2, which were mapped on chromoso me 3 and 11, respectively. VDH was also found to be controlled by poly genes. One dominant major gene, Ltnr3, and three dominant minor genes, Ltnr4, Ltnr5, and Ltnr6, were mapped on chromosomes 6, 9, 15 and 16, respectively. (C) 1998 Published by Elsevier Science Ltd on behalf of the International Society for Immunopharmacology.