MULTIPLE SIMULTANEOUS SYNTHESIS OF PHENOLIC LIBRARIES

A series of analogous arrays of small, non-peptidyl, non-oligomeric co mpounds were synthesized on polystyrene resin. With the aid of a funct ionally differentiated phenolic scaffold, the batch preparation of uni que benzamide and urea resins was accomplished, which were further der ivatized in modified 96-well plates. An efficient cleavage reaction of the phenyl benzoate link enabled the isolation of more than 600 pheno lic compounds in milligram quantities that were suitable for direct bi ological screening. The technology described herein represents a facil e, economical approach to non-peptidyl chemical diversity.