SPATIAL-ORGANIZATION OF HUMAN EEG DURING KETAMINE-ALTERED STATE OF CONSCIOUSNESS

Spatial organization of human EEG was studied by means of topographic mapping methods with the multiparametric data estimations in the state altered by ketamine in terms of the concept of coherent structures of brain electrical activity. Two main features of the altered state of consciousness were reflected in the opposite shifts: an increase in th e spatial synchronization in the left hemisphere (especially, in the p osterior area) and its decrease in the left frontal and right temporal one. The obtained data are discussed from the viewpoint of dissociati ve effects of ketamine at the neurochemical and neurophysiological lev els.