Na. Trekova et al., THE EFFECTS OF SEROTONIN ANTIBODIES ON BE HAVIOR AND BRAIN MONOAMINE CONTENT IN C57BL 6 MICE/, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 48(2), 1998, pp. 251-259
Mice of C57BL/6 strain were singly injected intraperitoneally with ant
obodies (AB) to serotonin (5-HT), The ''open-field'' testing in differ
ent periods after the AB injection revealed a depression of behavior w
ithin 1.5 h which changed for activation within 1 day and, again, depr
ession within 5 days after the injection. The analysis of neurotransmi
tter content in the sensorimotor cortex and hypothalamus revealed incr
eased levels of serotonin and, especially, dopamine in the cortex with
in 1 day, The cortex serotonin level within 5 days was also increased.
The possible mechanisms are discussed of neurotropic action of AB to
5-HT.