BRAIN MONOAMINE OXIDASES OF RATS BRED FOR PREDISPOSITION TO PENDULUM MOVEMENTS

Citation
Nn. Voitenko et al., BRAIN MONOAMINE OXIDASES OF RATS BRED FOR PREDISPOSITION TO PENDULUM MOVEMENTS, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 48(2), 1998, pp. 322-330
Citations number
32
Categorie Soggetti
Physiology,Neurosciences
ISSN journal
00444677
Volume
48
Issue
2
Year of publication
1998
Pages
322 - 330
Database
ISI
SICI code
0044-4677(1998)48:2<322:BMOORB>2.0.ZU;2-9
Abstract
Brain MAO activity was studied in male rats from the strains bred from Wistar stock for predisposition to pendulum movements (PM+) and for t he absence of such predisposition (PM-). By 16.00 o'clock, in PM+ rats MAO A activity significantly increased in the brain hemispheres and d ecreased in the brainstem, By this time, MAO B/MAO A ratio decreased i n the hemispheres and increased in the brainstem. Emotional (immobiliz ation) stress induced an increase in activity both of MAO A and MAO B in the brainstem of PM+ rats and increase only in MAO A activity in th e hemispheres of PM-rats. Actinomycin D abolished the effect of stress on MAO A and MAO B in PM+ rats but increased MAO A activity in the he mispheres of PM-rats. Possible molecular modifications are discussed i n regulation of MAO activity in PM+ rats.