Nn. Voitenko et al., BRAIN MONOAMINE OXIDASES OF RATS BRED FOR PREDISPOSITION TO PENDULUM MOVEMENTS, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 48(2), 1998, pp. 322-330
Brain MAO activity was studied in male rats from the strains bred from
Wistar stock for predisposition to pendulum movements (PM+) and for t
he absence of such predisposition (PM-). By 16.00 o'clock, in PM+ rats
MAO A activity significantly increased in the brain hemispheres and d
ecreased in the brainstem, By this time, MAO B/MAO A ratio decreased i
n the hemispheres and increased in the brainstem. Emotional (immobiliz
ation) stress induced an increase in activity both of MAO A and MAO B
in the brainstem of PM+ rats and increase only in MAO A activity in th
e hemispheres of PM-rats. Actinomycin D abolished the effect of stress
on MAO A and MAO B in PM+ rats but increased MAO A activity in the he
mispheres of PM-rats. Possible molecular modifications are discussed i
n regulation of MAO activity in PM+ rats.