OBJECTIVE: To investigate the correlation between the development of l
ow grade cervical intraepithelial neoplasia (LCIN) and human papilloma
virus (HPV) infection in cases with long-term follow-up. STUDY DESIGN:
Forty-three cases of LCIN were followed for more than five years with
cytology, colposcopy and Vira Pap. Coexistence of HPV infection was s
ought using a simplified HPV detection kit, the Vira Pap method (Dot B
lot hybridization). RESULTS: Regressive disease was noted in 21 cases,
and persistent and progressive disease was noted in 22 cases. HPV DNA
was negative in 81% (17 of 21) of regressive disease and positive in
55% (12 of 22) of persistent and progressive disease. LCIN had disappe
ared in 17 (63%) of 27 cases negative for HPV DNA and was persistent o
r progressive in 12 (75%) of 16 cases positive for HPV DNA. CONCLUSION
: The clinical course of LCIN correlates well with HPV infection.