LOW-GRADE CERVICAL INTRAEPITHELIAL NEOPLASIA ASSOCIATED WITH HUMAN-PAPILLOMAVIRUS INFECTION - LONG-TERM FOLLOW-UP

OBJECTIVE: To investigate the correlation between the development of l ow grade cervical intraepithelial neoplasia (LCIN) and human papilloma virus (HPV) infection in cases with long-term follow-up. STUDY DESIGN: Forty-three cases of LCIN were followed for more than five years with cytology, colposcopy and Vira Pap. Coexistence of HPV infection was s ought using a simplified HPV detection kit, the Vira Pap method (Dot B lot hybridization). RESULTS: Regressive disease was noted in 21 cases, and persistent and progressive disease was noted in 22 cases. HPV DNA was negative in 81% (17 of 21) of regressive disease and positive in 55% (12 of 22) of persistent and progressive disease. LCIN had disappe ared in 17 (63%) of 27 cases negative for HPV DNA and was persistent o r progressive in 12 (75%) of 16 cases positive for HPV DNA. CONCLUSION : The clinical course of LCIN correlates well with HPV infection.