SERUM SEX-HORMONE-BINDING GLOBULIN IS RELATED TO HEPATIC AND PERIPHERAL INSULIN SENSITIVITY BUT NOT TO BETA-CELL FUNCTION IN MEN AND WOMEN WITH TYPE-2 DIABETES-MELLITUS
I. Laing et al., SERUM SEX-HORMONE-BINDING GLOBULIN IS RELATED TO HEPATIC AND PERIPHERAL INSULIN SENSITIVITY BUT NOT TO BETA-CELL FUNCTION IN MEN AND WOMEN WITH TYPE-2 DIABETES-MELLITUS, Diabetic medicine, 15(6), 1998, pp. 473-479
This study examined the relationship of hepatic and peripheral insulin
sensitivity and beta-cell secretory function with serum sex hormone-b
inding globulin (SHBG) in men and women with Type 2 diabetes mellitus
(DM). Fasting insulin, glucose and SHBG were measured in 58 Type 2 dia
betic patients of both sexes (36 men) who were on diet treatment only
and terms for insulin sensitivity and beta-cell secretion obtained by
modelling. There was no significant difference in SHBG between men and
women despite similar degree of obesity. SHBG was positively correlat
ed (r = 0.41, p < 0.01) to hepatic insulin sensitivity derived from ma
thematical modelling of fasting glucose and insulin data using the hom
eostasis assessment model (HOMA). This relationship was independent of
gender (men, r = 0.48, p < 0.01; women, r = 0.45, p < 0.05). Fasting
insulin correlated negatively with SHBG in men (r = -0.34, p < 0.05).
There were also significant negative correlations between SHBG and eit
her plasma glucose (r = -0.29, p < 0.05) or body mass index (r = -0.34
, p < 0.05). SHBG did not correlate with HOMA-modelled beta-cell funct
ion. In a multiple regression analysis, SHBG was independently correla
ted only with insulin sensitivity (p < 0.05). Further studies in 15 of
the diabetic patients (11 men), showed a significant positive correla
tion (r = 0.52, p < 0.05) between SHBG and peripheral insulin sensitiv
ity derived by continuous infusion of glucose with model assessment (C
IGMA) but not between SHBG and CIGMA-modelled beta-cell function. Thes
e results indicate that both hepatic and peripheral insulin sensitivit
y are similarly related to serum SHBG in Type 2 diabetes of both sexes
. The sex-difference in SHBG was abolished in the patients. (C) 1998 J
ohn Wiley & Sons, Ltd.