SERUM SEX-HORMONE-BINDING GLOBULIN IS RELATED TO HEPATIC AND PERIPHERAL INSULIN SENSITIVITY BUT NOT TO BETA-CELL FUNCTION IN MEN AND WOMEN WITH TYPE-2 DIABETES-MELLITUS

Citation
I. Laing et al., SERUM SEX-HORMONE-BINDING GLOBULIN IS RELATED TO HEPATIC AND PERIPHERAL INSULIN SENSITIVITY BUT NOT TO BETA-CELL FUNCTION IN MEN AND WOMEN WITH TYPE-2 DIABETES-MELLITUS, Diabetic medicine, 15(6), 1998, pp. 473-479
Citations number
22
Categorie Soggetti
Endocrynology & Metabolism
Journal title
ISSN journal
07423071
Volume
15
Issue
6
Year of publication
1998
Pages
473 - 479
Database
ISI
SICI code
0742-3071(1998)15:6<473:SSGIRT>2.0.ZU;2-B
Abstract
This study examined the relationship of hepatic and peripheral insulin sensitivity and beta-cell secretory function with serum sex hormone-b inding globulin (SHBG) in men and women with Type 2 diabetes mellitus (DM). Fasting insulin, glucose and SHBG were measured in 58 Type 2 dia betic patients of both sexes (36 men) who were on diet treatment only and terms for insulin sensitivity and beta-cell secretion obtained by modelling. There was no significant difference in SHBG between men and women despite similar degree of obesity. SHBG was positively correlat ed (r = 0.41, p < 0.01) to hepatic insulin sensitivity derived from ma thematical modelling of fasting glucose and insulin data using the hom eostasis assessment model (HOMA). This relationship was independent of gender (men, r = 0.48, p < 0.01; women, r = 0.45, p < 0.05). Fasting insulin correlated negatively with SHBG in men (r = -0.34, p < 0.05). There were also significant negative correlations between SHBG and eit her plasma glucose (r = -0.29, p < 0.05) or body mass index (r = -0.34 , p < 0.05). SHBG did not correlate with HOMA-modelled beta-cell funct ion. In a multiple regression analysis, SHBG was independently correla ted only with insulin sensitivity (p < 0.05). Further studies in 15 of the diabetic patients (11 men), showed a significant positive correla tion (r = 0.52, p < 0.05) between SHBG and peripheral insulin sensitiv ity derived by continuous infusion of glucose with model assessment (C IGMA) but not between SHBG and CIGMA-modelled beta-cell function. Thes e results indicate that both hepatic and peripheral insulin sensitivit y are similarly related to serum SHBG in Type 2 diabetes of both sexes . The sex-difference in SHBG was abolished in the patients. (C) 1998 J ohn Wiley & Sons, Ltd.