A CASE OF PRIMARY SPLENIC LARGE-CELL LYMPHOMA WITH A T(9-14)(P13-Q32)

t(9;14)(p13;q32), a subtype of 14q32 translocation, plays an essential role in the development of lymphoplasmacytoid lymphoma. t(9;14)(p13;q 32) Causes juxtaposition of the PAX-5 gene on 9p13 and the IgH gene on 14q32, leading to the deregulation of the PAX-5 gene. We report a cas e of primary splenic lymphoma with a t(9;14). The histological diagnos is was diffuse large B-cell lymphoma without plasmacytoid differentiat ion. The lymphoma cells showed a complex karyotype including a t(9;14) . Southern blot analysis localized the breakpoint of the PAX-5 gene wi thin a couple of kb regions upstream of the exon ZA, although the invo lvement of the PAX-5 gene with the immunoglobulin heavy chain gene cou ld not be confirmed. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.