PHOSPHOLIPID-BINDING ACTIVITY OF HUMAN MANNAN-BINDING LECTIN

Some C-type lectins possess phospholipid-binding ability, which may be of physiological importance. Human mannan-binding lectin (MBL) was fo und to bind specifically to solid-phase phosphatidylserine (PS), phosp hatidylinositol (PI) and phosphatidylcholine (PC), but not cardiolipin (CL), in a concentration-dependent manner. This property was inhibite d by EDTA and by monosaccharides, and exhibited a similar pH dependenc e to the carbohydrate (mannan)-binding activity of MEL. These findings may be of immunological relevance. (C) 1998 Elsevier Science B.V. All rights reserved.