GLASS-IONOMERS - BIOACTIVE IMPLANT MATERIALS

Glass-ionomer cements (GICs) originally designed for use as dental mat erials have a number of advantages over acrylic bone cements. These in clude lack of exotherm during setting, absence of monomer and improved release of incorporated therapeutic agents; this has resulted in the development of GICs for biomedical applications. Major landmarks in th is history are the formulation of defined-composition ionomer glasses and an improved understanding of the biological and material propertie s of GICs. Following implantation, GICs can form a stable integration with bone, and affect the growth and development of bone, both adjacen t to their surface and systemically, through an ion release mechanism. The 'non-inert' nature of this group of materials is also demonstrate d by their adverse effects on neural tissue. Successful clinical use o f GICs, both as bone cements and as preformed implants for hard tissue replacement, have been reported in the fields of otologic surgery (Co chlear implant fixation, repair of the tympanic chain, eustation tube obliteration and as ear ossicles), and oral and reconstructive surgery . The use of GICs in situations where they will come into contact with nerves or neural tissue is contraindicated. (C) 1998 Published by Els evier Science Ltd. All rights reserved.