EFFECTS OF IRON AND DEFEROXAMINE ON CISPLATIN-INDUCED EMESIS - FURTHER EVIDENCE FOR THE ROLE OF FREE-RADICALS

Authors
MATSUKI N TORII Y SAITO H
Citation
N. Matsuki et al., EFFECTS OF IRON AND DEFEROXAMINE ON CISPLATIN-INDUCED EMESIS - FURTHER EVIDENCE FOR THE ROLE OF FREE-RADICALS, European journal of pharmacology. Environmental toxicology and pharmacology section, 248(4), 1993, pp. 329-331
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Toxicology
Journal title
European journal of pharmacology. Environmental toxicology and pharmacology section → ACNP
ISSN journal
09266917
Volume
248
Issue
4
Year of publication
1993
Pages
329 - 331
Database
ISI
SICI code
0926-6917(1993)248:4<329:EOIADO>2.0.ZU;2-J
Abstract
The effects of ferric chloride and deferoxamine, an iron chelator, on cisplatin-induced emesis were studied in Suncus murinus. Pretreatment with ferric chloride (FeCl3, 16-64 mg/kg) increased the number of 20 m g/kg cisplatin-induced vomiting episodes. Deferoxamine (256 mg/kg) sig nificantly reduced the number of vomiting episodes and prolonged the l atency. These results further support the involvement of free radicals in the generation of cisplatin-induced emesis.