INCREASED ENDOTHELIAL GENE-EXPRESSION OF ANGIOTENSIN AT(1A) RECEPTOR IN CYCLOSPORINE-INDUCED HYPERTENSIVE RATS

Authors
IWAI J KANAYAMA Y INOUE NNT OKAMURA M TAKEDA T
Citation
J. Iwai et al., INCREASED ENDOTHELIAL GENE-EXPRESSION OF ANGIOTENSIN AT(1A) RECEPTOR IN CYCLOSPORINE-INDUCED HYPERTENSIVE RATS, European journal of pharmacology. Environmental toxicology and pharmacology section, 248(4), 1993, pp. 341-344
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Toxicology
Journal title
European journal of pharmacology. Environmental toxicology and pharmacology section → ACNP
ISSN journal
09266917
Volume
248
Issue
4
Year of publication
1993
Pages
341 - 344
Database
ISI
SICI code
0926-6917(1993)248:4<341:IEGOAA>2.0.ZU;2-F
Abstract
We examined the gene expression of angiotensin AT(1A) receptors in aor tic endothelial cells of cyclosporine induced hypertensive rats using reverse transcribed polymerase chain reaction method. The gene express ion of angiotensin AT(1A) receptors in aortic endothelial cells of cyc losporine induced hypertensive rats showed a two-fold increase when co mpared with that in normotensive control rats. These results raise a p ossibility that the up-regulation of endothelial angiotensin AT(1A) re ceptors participates in the pathogenesis of cyclosporine induced hyper tension.