ROXITHROMYCIN INHIBITS CYTOKINE PRODUCTION BY AND NEUTROPHIL ATTACHMENT TO HUMAN BRONCHIAL EPITHELIAL-CELLS IN-VITRO

Authors
KAWASAKI S TAKIZAWA H OHTOSHI T TAKEUCHI N KOHYAMA T NAKAMURA H KASAMA T KOBAYASHI K NAKAHARA K MORITA Y YAMAMOTO K
Citation
S. Kawasaki et al., ROXITHROMYCIN INHIBITS CYTOKINE PRODUCTION BY AND NEUTROPHIL ATTACHMENT TO HUMAN BRONCHIAL EPITHELIAL-CELLS IN-VITRO, Antimicrobial agents and chemotherapy, 42(6), 1998, pp. 1499-1502
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
6
Year of publication
1998
Pages
1499 - 1502
Database
ISI
SICI code
0066-4804(1998)42:6<1499:RICPBA>2.0.ZU;2-5
Abstract
We evaluated the effect of roxithromycin on cytokine production and ne utrophil attachment to human airway epithelial cells. Roxithromycin su ppressed production of interleukin 8 (IL-8), IL-6, and granulocyte-mac rophage colony-stimulating factor. It inhibited neutrophil adhesion to epithelial cells. Roxithromycin modulates local recruitment and activ ation of inflammatory cells, which may have relevance to its efficacy in airway diseases.