POSTANTIBIOTIC EFFECT OF TROVAFLOXACIN AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE ORGANISMS

Authors
PANKUCH GA JACOBS MR APPELBAUM PG
Citation
Ga. Pankuch et al., POSTANTIBIOTIC EFFECT OF TROVAFLOXACIN AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE ORGANISMS, Antimicrobial agents and chemotherapy, 42(6), 1998, pp. 1503-1505
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
6
Year of publication
1998
Pages
1503 - 1505
Database
ISI
SICI code
0066-4804(1998)42:6<1503:PEOTAG>2.0.ZU;2-A
Abstract
Trovafloxacin pneumococcal and staphylococcal postantibiotic effects ( PAEs) were 0.7 to 1.8 and 0.7 to 2.4 h, respectively. For Escherichia coli and Pseudomonas aeruginosa, PAEs were 2.4 to 4.4 h. Pneumococcal and staphylococcal postantibiotic sub-MIC effects (PA-SMEs) (0.4 times the MIC) were 2.3 to 3.7 and 2.4 to >9.2 h, respectively, and E. coli PA-SMEs (0.3 times the MIC) were 6.8 to >12.0 h. For one P. aeruginos a strain, the PA-SME (0.4 times the MIC) was >10 h; in the other, rapi d bactericidal activity precluded measurement.