IN-VITRO ACTIVITIES OF THE NEW KETOLIDE ANTIBIOTICS HMR-3004 AND HMR-3647 AGAINST STREPTOCOCCUS-PNEUMONIAE IN GERMANY

The comparative in vitro activity of HMR 3004 and HMR 3647, new ketoli de antibiotics, was tested by a standard agar dilution technique again st 221 pneumococcal strains, including isolates with intermediate leve ls of resistance to penicillin and erythromycin-resistant isolates. Th e ketolides were more active than other macrolides and showed excellen t activity against erythromycin-resistant strains. All the strains wer e inhibited by less than or equal to 2 mu g of HMR 3004/ml or by less than or equal to 0.5 mu g of HMR 3647/ml.