ENZYME REPLACEMENT THERAPY DECREASES HYPERGAMMAGLOBULINEMIA IN GAUCHERS-DISEASE

Authors
DEIBENER J KAMINSKY P JACOB C DOUSSET B KLEIN M DUC M
Citation
J. Deibener et al., ENZYME REPLACEMENT THERAPY DECREASES HYPERGAMMAGLOBULINEMIA IN GAUCHERS-DISEASE, Haematologica, 83(5), 1998, pp. 479-480
Citations number
10
Categorie Soggetti
Hematology
Journal title
Haematologica → ACNP
ISSN journal
03906078
Volume
83
Issue
5
Year of publication
1998
Pages
479 - 480
Database
ISI
SICI code
0390-6078(1998)83:5<479:ERTDHI>2.0.ZU;2-9
Abstract
We report the effects of enzyme replacement therapy in a patient with Gaucher's disease associated with a monoclonal gammopathy. Alglucerase induces a linear decline in immunoglobulin and beta(2)-microglobulin levels. This observation suggests that this treatment decreases the ch ronic antigenic stimulation commonly found in Gaucher's disease.