A STEREOCONTROLLED SYNTHESIS OF MONOFLUORO KETOMETHYLENE DIPEPTIDE ISOSTERES

Authors
HOFFMAN RV TAO JH
Citation
Rv. Hoffman et Jh. Tao, A STEREOCONTROLLED SYNTHESIS OF MONOFLUORO KETOMETHYLENE DIPEPTIDE ISOSTERES, Tetrahedron letters, 39(24), 1998, pp. 4195-4198
Citations number
33
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
24
Year of publication
1998
Pages
4195 - 4198
Database
ISI
SICI code
0040-4039(1998)39:24<4195:ASSOMK>2.0.ZU;2-M
Abstract
A simple, stereocontrolled synthesis of monofluoro ketomethylene dipep tide isosteres has been developed. The method is short (6 steps) and d iastereoselective (85-95% de) and enantioselective (>95% ee). (C) 1998 Elsevier Science Ltd. All rights reserved.