A CONVENIENT SYNTHESIS OF 5'-AMINO-5'-DEOXYTHYMIDINE AND PREPARATION OF PEPTIDE-DNA HYBRIDS

Authors
TETZLAFF CN SCHWOPE I BLECZINSKI CF STEINBERG JA RICHERT C
Citation
Cn. Tetzlaff et al., A CONVENIENT SYNTHESIS OF 5'-AMINO-5'-DEOXYTHYMIDINE AND PREPARATION OF PEPTIDE-DNA HYBRIDS, Tetrahedron letters, 39(24), 1998, pp. 4215-4218
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
24
Year of publication
1998
Pages
4215 - 4218
Database
ISI
SICI code
0040-4039(1998)39:24<4215:ACSO5A>2.0.ZU;2-T
Abstract
5'-Amino-5'-deoxythymidine was prepared from thymidine in two steps an d converted to its known 5'-methoxytrityl-protected 3'-phosphoramidite building block for DNA assembly on solid supports. Using this buildin g block, peptide-DNA hybrids were synthesized in stepwise manner or vi a fragment condensation, both as single compounds and as small combina torial libraries. (C) 1998 Elsevier Science Ltd. All rights reserved.