DIPHENYLPHOSPHINOOXAZOLINE LIGANDS WITH A CHIRAL BINAPHTHYL BACKBONE FOR PD-CATALYZED ALLYLIC ALKYLATION

Novel diphenylphosphinooxazoline ligands with a chiral binaphthyl back bone were prepared. It was interestingly found that the two diastereom eric ligands afforded two enantiomeric products, respectively, with ex cellent catalytic activities and enantioselectivities for the palladiu m-catalyzed allylic alkylation, regardless of the identical (S)-oxazol ine ring existing in both ligands. This is the first example using an (S)-oxazoline ligand to afford an (R)-product for this reaction. (C) 1 998 Elsevier Science Ltd. All rights reserved.