SYNTHESIS OF HYDROPEROXIDE AND PERKETAL DERIVATIVES OF POLYUNSATURATED FATTY-ACIDS AS POTENTIAL ANTIMALARIAL AGENTS

Authors
PITT MJ EASTON CJ ROBERTSON TA KUMARATILAKE LM FERRANTE A POULOS A RATHJEN DA
Citation
Mj. Pitt et al., SYNTHESIS OF HYDROPEROXIDE AND PERKETAL DERIVATIVES OF POLYUNSATURATED FATTY-ACIDS AS POTENTIAL ANTIMALARIAL AGENTS, Tetrahedron letters, 39(24), 1998, pp. 4401-4404
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
24
Year of publication
1998
Pages
4401 - 4404
Database
ISI
SICI code
0040-4039(1998)39:24<4401:SOHAPD>2.0.ZU;2-4
Abstract
Hydroperoxide derivatives of beta-oxa-substituted polyunsaturated fatt y acids were prepared by 15-lipoxygenase catalysed oxidation and perke tal derivatives of fatty acid hydroperoxides were synthesized. The per ketals are more stable than their parent fatty acid hydroperoxides, bu t less active as antimalarial agents in the in vitro growth inhibition of Plasmodium falciparum. (C) 1998 Elsevier Science Ltd. All rights r eserved.