BRIDGEHEAD NITROGEN HETEROCYCLIC-SYSTEMS - SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF S-TRIAZOLO[3,4-B][1,3,4]THIADIAZOLES, S-TRIAZOLO[3,4-B][1,3,4]THIADIAZINES AND S-TRIAZOLO[3',4' 2,3]-THIADIAZINO-[5,6-B]QUINOXALINE/

The condensation of 3-n-propyl-4-amino-5-mercapto-s-triazolo 1 with ch loroacetic acid, alpha-haloketone, benzoin, bromoacetaldehyde diethyl acetal, 2,3-dichloroquinoxaline, carbon disulphide, aromatic carboxyli c acids and aromatic carboxaldehydes furnished in one-step the cyclic products, yl-7H-s-triazolo[3,4-b][1,3,4]thiadiazin-6(5H)-one 2, -3-n-p ropyl-7H-s-triazolo[3,4-b][1,3,4]thiadiazine 3, 3-n-propyl-6,7-dipheny l-5H-s-triazolo[3,4-b] [1,3,4]-thiadiazine 4, 3-n-propyl-7H-s-triaolo[ 3,4-b]-[1,3,4]thiadiazine hydrobromide 5, lo-[3',4':2,3][1,3,4]thiadia zino[5,6-b]quinoxaline 6, 3-n-propyl-s-triazolo [3,4-b] [1,3,4] thiadi aole-6(5H)-thione 7, 3-n-propyl-6-aryl-s-triazolo [3,4-b] [1,3,4]thiad iazoles 8 and -5,6-dihydro-3n-propyl-s-triazolo[3,4]thiadiazoles 9 res pectively, on the basis of elemental analysis and spectral data. The a ntibacterial and antifungal activity of some of the compound have also been evaluated.