REMOVAL OF TOXIC PRESERVATIVES IN PHARMACEUTICAL PREPARATIONS OF INSULIN BY THE USE OF ULTRA-STABLE ZEOLITE-Y

Ultra-stable zeolite Y and mordenite with pore sizes of 0.75 and 0.70 nm, respectively, showed the capacity to bind phenol acid m-cresol rap idly. Phenol and m-cresol are used as preservatives in pharmaceutical preparations for humans and, with the use of a 15 mg filter of ultra-s table zeolite Y, 98% of the preservative in a 200 mu l pharmaceutical insulin preparation, Actrapid(R), was removed after 5 s of passage thr ough the filter. The insulin content in the filtrate was not disminish ed.