INVESTIGATION ON 5 NOVEL SUBSTITUTED BETA-CYCLODEXTRINS USED AS GC STATIONARY PHASES

Five beta-cyclodextrin derivatives, takis[2,6-di-O-pentyl-3-O-(4-nitro benzyl))-beta-CD (CD-I), heptakis [2,6-di-O-pentyl-3-O-(5-hexenyl)]- b eta-CD(CD-II), heptakis-(2, 6-di-O-cinnamyl-3-O-methyl)-beta-CD(CD-III ), heptakis-(2, 6-di-O-cinnamyl-3-O-acetyl)-beta-CD(CD-IV) and heptaki s(2, -di-O-cinnamyl-3-O-trifluoroacetyl)-beta-CD(CD-V), were synthesiz ed and coated on fused-silica capillary columns. Their chromatographic characteristics were tested and compared with heptakis (2,3,6-tri-O-p entyl)-beta-CD (CD-VI) and heptakis 2,6-di-O-pentyl-3-O-trifluoroacety l)-beta-CD(CD-It was found that the size, polarity, and aromatic prope rty of the substituted group at the 3-position of heptakis(2,6-di-O-pe ntyl)-beta-cyclodextrins greatly influenced their chromatographic prop erties and separation ability. The introduction of aromatic group or a group containing a double-bond may bring pi-pi interactions between t he host and guest molecules, and therefore increased the separation ab ility of the beta-CDs for substituted benzene isomers. Introduction of cinnamyl groups in to the 2,6-3-position of beta-CD has a significant effect on the chromatographic properties of the stationary phases(CD- III-CD-V).