EFFECT OF SINGLE AND DIVIDED DOSE ADMINISTRATION ON THE PHARMACOKINETICS OF ALBENDAZOLE IN SHEEP AND GOAT

Authors
SANYAL PK
Citation
Pk. Sanyal, EFFECT OF SINGLE AND DIVIDED DOSE ADMINISTRATION ON THE PHARMACOKINETICS OF ALBENDAZOLE IN SHEEP AND GOAT, Veterinary journal, 155(3), 1998, pp. 311-316
Citations number
21
Categorie Soggetti
Veterinary Sciences
Journal title
Veterinary journal → ACNP
ISSN journal
10900233
Volume
155
Issue
3
Year of publication
1998
Pages
311 - 316
Database
ISI
SICI code
1090-0233(1998)155:3<311:EOSADD>2.0.ZU;2-4
Abstract
The pharmacokinetics of albendazole were studied in sheep and goats fo llowing single and divided dose administration at nematocidal and fluk icidal dose rates. The disposition curves of the metabolites indicated increased uptake of the drug both in sheep and goats at divided dose schedules compared to single dose administration (P<0.05). The increas ed bioavailability of benzimidazole anthelmintics in divided dose sche dules could improve their efficacy and help in extending their lives.