Pk. Sanyal, EFFECT OF SINGLE AND DIVIDED DOSE ADMINISTRATION ON THE PHARMACOKINETICS OF ALBENDAZOLE IN SHEEP AND GOAT, Veterinary journal, 155(3), 1998, pp. 311-316
The pharmacokinetics of albendazole were studied in sheep and goats fo
llowing single and divided dose administration at nematocidal and fluk
icidal dose rates. The disposition curves of the metabolites indicated
increased uptake of the drug both in sheep and goats at divided dose
schedules compared to single dose administration (P<0.05). The increas
ed bioavailability of benzimidazole anthelmintics in divided dose sche
dules could improve their efficacy and help in extending their lives.