NEW-GENERATION DOPAMINERGIC AGENTS 4 - EXPLOITING THE 2-METHYL CHROMAN SCAFFOLD - SYNTHESIS AND EVALUATION OF 2 NOVEL SERIES OF OMETHYL)-3,4,7,9-TETRAHYDRO-2H-PYRANO[2,3-E]INDOLE AND INDOL-8-ONE DERIVATIVES

Authors
MEWSHAW RE MARQUIS KL SHI XJ MCGAUGHEY G STACK G WEBB MB ABOUGHARBIA M WASIK T SCERNI R SPANGLER T BRENNAN JA MAZANDARANI H COUPET J ANDREE TH
Citation
Re. Mewshaw et al., NEW-GENERATION DOPAMINERGIC AGENTS 4 - EXPLOITING THE 2-METHYL CHROMAN SCAFFOLD - SYNTHESIS AND EVALUATION OF 2 NOVEL SERIES OF OMETHYL)-3,4,7,9-TETRAHYDRO-2H-PYRANO[2,3-E]INDOLE AND INDOL-8-ONE DERIVATIVES, Tetrahedron, 54(25), 1998, pp. 7081-7108
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
25
Year of publication
1998
Pages
7081 - 7108
Database
ISI
SICI code
0040-4020(1998)54:25<7081:NDA4-E>2.0.ZU;2-W
Abstract
The rational design, synthesis, and evaluation of two novel series of omethyl)-3,4,7,9-tetrahydro-2H-pyrano[2,3-e]indole and indolone deriva tives rue disclosed, based on the recently discovered D-2 agonist phen olic template prototype [i.e. the 7-OH-2-(aminomethyl)chroman nucleus] . The indolones were observed to have higher affinity and intrinsic ac tivity than the corresponding indoles. (C) 1998 Elsevier Science Ltd. All rights reserved.