TOTAL SYNTHESIS OF 26-HYDROXY-EPOTHILONE-B AND RELATED ANALOGS VIA A MACROLACTONIZATION BASED STRATEGY

Authors
NICOLAOU KC FINLAY MRV NINKOVIC S SARABIA F
Citation
Kc. Nicolaou et al., TOTAL SYNTHESIS OF 26-HYDROXY-EPOTHILONE-B AND RELATED ANALOGS VIA A MACROLACTONIZATION BASED STRATEGY, Tetrahedron, 54(25), 1998, pp. 7127-7166
Citations number
40
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
25
Year of publication
1998
Pages
7127 - 7166
Database
ISI
SICI code
0040-4020(1998)54:25<7127:TSO2AR>2.0.ZU;2-8
Abstract
The chemical synthesis of a series of 26-substituted epothilones B is described. Fully protected 26-hydroxydesoxyepothilone B (7), prepared via the macrolactonization strategy, served as a common precursor to t he designed epothilones described. The synthesized compounds were memb ers of a large epothilone library whose biological screening led to th e identification of a number of highly potent antitumor agents. (C) 19 98 Elsevier Science Ltd. All rights reserved.