Me. Mussolino et al., RISK-FACTORS FOR HIP FRACTURE IN WHITE MEN - THE NHANES-I EPIDEMIOLOGIC FOLLOW-UP-STUDY, Journal of bone and mineral research, 13(6), 1998, pp. 918-924
This prospective population-based study assessed predictors of hip fra
cture risk in white men, Participants were members of the Epidemiologi
c Follow-up Study cohort of the First National Health and Nutrition Ex
amination Survey, a nationally representative sample of noninstitution
alized civilians who were followed for a maximum of 22 years, A cohort
of 2879 white men (2249 in the nutrition and weight-loss subsample, 1
437 in the bone density subsample) aged 45-74 years at baseline (1971-
1975) were observed through 1992, Ninety-four percent of the original
cohort were successfully traced. Hospital records and death certificat
es were used to identify a total of 71 hip fracture cases (61 in the n
utrition and weight-loss subsample, 26 in the bone-density subsample),
Among the factors evaluated were age at baseline, previous fractures
other than hip, body mass index, smoking status, alcohol consumption,
nonrecreational physical activity, weight loss from maximum, calcium i
ntake, number of calories, protein consumption, chronic disease preval
ence, and phalangeal bone density, The risk adjusted relative risk (RR
) of hip fracture was significantly associated with presence of one or
more chronic conditions (RR = 1.91, 95% confidence interval ICI] = 1.
19-3.06), weight loss from maximum greater than or equal to 10% (RR =
2.27, 95% CI 1.13-4.59), and 1 SD change in phalangeal bone density (R
R = 1.73, 95% CI 1.11-2.68), No other variables were significantly rel
ated to hip fracture risk Although based on a small number of cases, t
his is one of the first prospective studies to relate weight loss and
bone density to hip fracture risk in men.