RISK-FACTORS FOR HIP FRACTURE IN WHITE MEN - THE NHANES-I EPIDEMIOLOGIC FOLLOW-UP-STUDY

Citation
Me. Mussolino et al., RISK-FACTORS FOR HIP FRACTURE IN WHITE MEN - THE NHANES-I EPIDEMIOLOGIC FOLLOW-UP-STUDY, Journal of bone and mineral research, 13(6), 1998, pp. 918-924
Citations number
56
Categorie Soggetti
Endocrynology & Metabolism
ISSN journal
08840431
Volume
13
Issue
6
Year of publication
1998
Pages
918 - 924
Database
ISI
SICI code
0884-0431(1998)13:6<918:RFHFIW>2.0.ZU;2-#
Abstract
This prospective population-based study assessed predictors of hip fra cture risk in white men, Participants were members of the Epidemiologi c Follow-up Study cohort of the First National Health and Nutrition Ex amination Survey, a nationally representative sample of noninstitution alized civilians who were followed for a maximum of 22 years, A cohort of 2879 white men (2249 in the nutrition and weight-loss subsample, 1 437 in the bone density subsample) aged 45-74 years at baseline (1971- 1975) were observed through 1992, Ninety-four percent of the original cohort were successfully traced. Hospital records and death certificat es were used to identify a total of 71 hip fracture cases (61 in the n utrition and weight-loss subsample, 26 in the bone-density subsample), Among the factors evaluated were age at baseline, previous fractures other than hip, body mass index, smoking status, alcohol consumption, nonrecreational physical activity, weight loss from maximum, calcium i ntake, number of calories, protein consumption, chronic disease preval ence, and phalangeal bone density, The risk adjusted relative risk (RR ) of hip fracture was significantly associated with presence of one or more chronic conditions (RR = 1.91, 95% confidence interval ICI] = 1. 19-3.06), weight loss from maximum greater than or equal to 10% (RR = 2.27, 95% CI 1.13-4.59), and 1 SD change in phalangeal bone density (R R = 1.73, 95% CI 1.11-2.68), No other variables were significantly rel ated to hip fracture risk Although based on a small number of cases, t his is one of the first prospective studies to relate weight loss and bone density to hip fracture risk in men.