TIGLOYLCHOLINE - A NEW CHOLINE ESTER TOXIN FROM THE HYPOBRANCHIAL GLAND OF 2 SPECIES OF MURICID GASTROPODS (THAIS-CLAVIGERA AND THAIS-BRONNI)

Authors
SHIOMI K ISHII M SHIMAKURA K NAGASHIMA Y CHINO M
Citation
K. Shiomi et al., TIGLOYLCHOLINE - A NEW CHOLINE ESTER TOXIN FROM THE HYPOBRANCHIAL GLAND OF 2 SPECIES OF MURICID GASTROPODS (THAIS-CLAVIGERA AND THAIS-BRONNI), Toxicon, 36(5), 1998, pp. 795-798
Citations number
7
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon → ACNP
ISSN journal
00410101
Volume
36
Issue
5
Year of publication
1998
Pages
795 - 798
Database
ISI
SICI code
0041-0101(1998)36:5<795:T-ANCE>2.0.ZU;2-#
Abstract
Crude extracts from hypobranchial glands of two species of muricid gas tropods, Thais clavigera and Thais bronni, were highly lethal to mice. Regardless of species, a new choline ester was isolated as the major toxic principle and elucidated to be tigloylcholine, a structural isom er of senecioylcholine widely found in gastropod hypobranchial glands, by H-1- and C-13-NMR as well as FAB-MS. The i.v. LD50 (mouse) of tigl oylcholine was estimated to be 0.92 mg/kg, (C) 1998 Elsevier Science L td. All rights reserved.