EFFECT OF AVENE SPRING WATER ON THE ACTIVATION OF RAT MAST-CELL BY SUBSTANCE-P OR ANTIGEN

Authors
JOLY F CHARVERON M ARIES MF BIDAULT J KAHHAK L BEAUVAIS F GALL Y
Citation
F. Joly et al., EFFECT OF AVENE SPRING WATER ON THE ACTIVATION OF RAT MAST-CELL BY SUBSTANCE-P OR ANTIGEN, SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY, 11(2), 1998, pp. 111-116
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy","Dermatology & Venereal Diseases
Journal title
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY → ACNP
ISSN journal
14222868
Volume
11
Issue
2
Year of publication
1998
Pages
111 - 116
Database
ISI
SICI code
1422-2868(1998)11:2<111:EOASWO>2.0.ZU;2-I
Abstract
The biological activity of Avene water from two different springs ('Sa inte Odile' and 'Val d'Orb') was studied in vitro on rat peritoneal ma st cell activation. A dilution-dependent inhibition of both histamine and prostaglandin D-2 antigen-induced release was observed when cells were preincubated with both Avene spring waters. They also inhibited h istamine release triggered by substance P, The ability of Avene water to inhibit mast cell activation in vitro may be related with its antia llergic and anti-inflammatory properties and its use in hydrotherapy.