All infants born at Al An Hospital, United Arab Emirates between 1 Jan
uary and 30 June 1995 who developed clinically relevant hyperbilirubin
aemia defined as jaundice requiring investigation and treatment were p
rospectively studied. Of the 2300 live births, 85 (3.7%) developed hyp
erbilirubinaemia. Of these, 22 were premature, 22 had ABO haemolytic d
isease of the newborn, eight had G6PD deficiency (Mediterranean), seve
n had breast-milk jaundice, five were born to mothers with diabetes me
llitus and one had Rh incompatibility. No specific factor was identifi
ed in 20 (24%). Significant differences in the distribution of diagnos
tic categories were found among the major ethnic groups in the populat
ion studied. This first study of the epidemiology of clinically releva
nt hyperbilirubinaemia in this community identified locally relevant r
isk factors and highlighted areas of health care which, if modified, m
ight reduce the incidence of hyperbilirubinaemia.