SUCCESSFUL FETAL-OUTCOME AFTER EXPOSURE TO IDARUBICIN AND CYTOSINE-ARABINOSIDE DURING THE 2ND-TRIMESTER OF PREGNANCY - A CASE-REPORT

Chemotherapeutic agents administered to the mother during pregnancy ma y severely jeopardize the fetus. We describe a newborn girl who had be en exposed to idarubicin and cytosine-arabinoside during the second an d third trimesters oi pregnancy due to treatment of newly diagnosed ac ute myeloid leukemia in the mother. The child had no structural congen ital abnormalities. Adverse effects observed were prematurity, growth retardation, mildly disturbed transaminases and erythroblastosis, all of which were self-limiting with no permanent sequelae.